Symposium
The 15th Symposium The 16th Symposium
The 16th Symposium
“Mechanotransduction and Pain”

October 4~7, 2022

It is my great honor to host the 16th Aslla symposium, an International Symposium held on Oct 4~6, 2022 in Gangneung, Korea.
The subtitle is “Mechanotransduction and Pain”. Obviously, mechanotransduction is an emerging field of research that focuses on how physical 
forces in cells or tissues regulate cellular or physiological functions. Mechanotransdution defines the molecular and cellular processes of 
conversion of various mechanical stimuli to biological functions. Therefore, mechanotransduction mediates numerous body functions such
as touch, proprioception,  pain, and hearing. Cellular events include embryonic development, stem cell lineage, cell migration, and tumorigenesis.
In the Aslla Symposium, recent findingson various mechanotransduction channels will be discussed. In addition, cellular mechanotransduction
processes will also be introduced. Pain is another important topic in this symposium. Pain research is critical for maintaining human’s quality life. 
However, the treatment of chronic pain is not   fulfilled, yet, mainly because its etiology  is complex. In the symposium, experts
from different fields of pain research will introduce novel ideas on pain mechanisms. In addition, novel candidate chemicals for treating
chronic pain will be introduced. As world-renowned researchers are invited, this symposium is a good chance to satisfy your hunger for novel theories and ideas. 
Aslla is an old name of Gangneung city, a port city in the eastern part of Korea. Surrounded by mountains and clean ocean, 
Gangneung is one of the most popular resorts in Korea.  You will enjoy the scenery as well as the symposium. 
More importantly, the symposium registration is free. You are cordially welcome!

Uhtaek Oh, KIST
Chair
Organizing Committee

Organizer & Main Speaker
  • Organizer
    사진
    Uhtaek Oh

    Professor

    KIST

  • Main Speaker
    사진
    Min Zhou

    Professor

    University of Toronto

  • Main Speaker
    사진
    Rohini Kuner

    Professor

    Heidelberg University

  • Main Speaker
    사진
    Yan Jie

    Professor

    National University of Singapore

  • Main Speaker
    사진
    John Wood

    Professor

    University College London

  • Main Speaker
    사진
    Makoto Tominaga

    Professor

    National Institute for Physiological Sciences

  • Main Speaker
    사진
    Jeffrey Holt

    Professor

    Harvard University

  • Main Speaker
    사진
    Bailong Xiao

    Professor

    Tsinghua University

  • Main Speaker
    사진
    Eric Honore

    Professor

    Centre National de la Recherche Scientifique

  • Main Speaker
    사진
    Boris Martinac

    Professor

    Victor Chang Cardiac Research Institute

  • Main Speaker
    사진
    C. Justin Lee

    Professor

    Institute for Basic Science

Participants
Organizers
Uhtaek Oh Korea Institute of Science and Technology (KIST)
Speakers
Min Zhou University of Toronto
Rohini Kuner Heidelberg University
Yan Jie National University of Singapore
John Wood Mechanosensation and pain; from genes to drugs
Makoto Tominaga National Institute for Physiological Sciences
Jeffrey Holt Harvard University
Bailong Xiao Tsinghua University
Eric Honore Centre National de la Recherche Scientifique
Boris Martinac Victor Chang Cardiac Research Institute
C. Justin Lee  Institute for Basic Science
Choong-Wan Woo Institute for Basic Science
Seog Bae OH Seoul National University
 Chungho Kim Korea University
Dong-Hwee Kim Korea University
Sun Wook Hwang Korea University
Woongbin Kim iN Therapeutics
Kyuhyung Kim DGIST
Gyusang Hong Korea Institute of Science and Technology (KIST)
Tae Song Kim Korea Institute of Science and Technology (KIST)
Program
Date Time Schedule
Day 1 (Oct 4th) 12:00 ~ 13:00 Registration
13:00 ~ 13:10 Opening Remark (Uhtaek Oh, KIST, Korea)
13:10 ~ 15:50 Session 1: Pain in the complex systems
(Chair: Seog Bae Oh)
13:10 ~ 14:00 Cortical LTPs as key mechanisms for chronic pain and anxiety
(Min Zhuo, Toronto Univ., Canada)  *Video Conferencing
14:00 ~ 14:50 Structural plasticity in neural pathways and peripheral miswiring of sensory end organs in neuropathic pain
(Rohini Kuner, Heidelberg Univ., Germany) *Video Conferencing 
14:50 ~ 15:20 Developing fMRI-based biomarkers for pain
(Choong-Wan Woo, IBS, Korea) 
15:20 ~ 15:50 Neuroimmune crosstalk in peripheral neuropathy : role of natural killer cells
(Seog Bae Oh, Seoul Natl. Univ., Korea)
15:50 ~ 16:10 Coffee Break
16:10 ~ 18:00 Session 2: Mechanobiology  (Chair: Yan Jie)
16:10 ~ 17:00 The mechanical activation of talin and vinculin
(Yan Jie, Natl. Univ. of Singapore, Singapore)
17:00 ~ 17:30 Integrin activation by membrane tension
(Chungho Kim, Korea Univ., Korea) 
17:30 ~ 18:00 Nuclear Mechanobiology: Biological interpretation of subcellular nuclear mechanics   
(Donghwee Kim, Korea U)      
18:00 ~ 21:00 Welcome Dinner (Gangneung City)
Day 2 (Oct 5th) 09:30 ~ 12:50 Session 3: Ion channels in pain
(Chair: Myungha Yoon)
09:30 ~ 10:10 Anoctamin 1 in itch and pain
(Uhtaek Oh, KIST, Korea)
10:10 ~ 11:00 TRP channels and Pain
(Makoto Tominaga, NIPS, Japan) 
11:00 ~ 11:30 New TRP channel tuner GPRs for pain modulation
(Sun Wook Hwang, Korea Univ., Korea)
11:30 ~ 12:20 From genes to analgesic drugs
(John N Wood, Univ. College London, UK)     
12:20 ~ 12:50 Nav1.7 blockers for pain treatment
(Woongbin Kim, iN Therapeutics, Korea)
12:50 ~ 14:10 Luncheon
14:10 ~ 18:00 Session 4: Mechanosensitive ion channels (1) (Chair: Uhtaek Oh)
14:10 ~ 15:00 Next generation gene therapies for genetic hearing loss
(Jeffrey Holt, Harvard Univ., USA)
*Video Conferencing
15:00 ~ 15:50 Feeling force with PIEZOs     
(Bailong Xiao, Tsing Hua Univ., China)
Video Conferencing                   
15:50 ~ 16:40 Collective behavior of force-gated ion channels
(Eric Honoré, CNRS, France)      
16:40 ~ 17:10 Mechanosensitive piezo channel, PIEZO-1, regulates food deglutition in C. Elegans
(Kyuhyung Kim, DGIST, Korea)                         
17:10 ~ 18:00 Tentonin 3, a mechanosensitive channel: its biophysics and physiology
(Uhtaek Oh, KIST, Korea)
18:00 ~ 21:00 Dinner (Gangneung City)
Day 3 (Oct 6th)   09:30 ~ 12:10 Session 5: Mechanosensitive ion channels (2)
(Chair: C. Justin Lee)
  09:30 ~ 10:20 3.8 billion years of mechanosensory transduction:
'What is true for E. coli true for the elephant'  
(Boris Martinac, Victor Chang Cardiac Res. Inst., Australia) 
  10:20 ~ 11:10 Ultrasonogenetic neuromodulation via astrocytic TRPA1  
(C. Justin Lee, IBS, Korea)
  11:10 ~ 11:40 Tentonin 3 and cytoskeletons
(Gyu-Sang Hong, KIST, Korea)
  11:40 ~ 12:10 In vitro analysis of the electrophysiological characteristics of mechanosensitive ion channel: Tentonin 3/TMEM150c
(Taesong Kim, KIST, Korea)  
12:10 ~ 13:00 Luncheon
13:00 ~ 18:00 Excursion (Goseong DMZ)
18:00 ~ 21:00 Banquet (Gangneung City)
Day 4 (Oct 7th) 10:00 ~ 11:50 Group Discussion & Farewell
11:50 ~ 12:00 Closing Remark
(Uhtaek Oh, KIST, Korea)